The neutrino velocity anomaly as an explanation of the missing observation of neutrinos in coincidence with GRB

The search for neutrinos emitted in coincidence with Gamma-Bay Burst has been so far unsuccessfully. In this paper we show that the recent result reported by the OPERA Collaboration on an early arrival time of muon neutrinos with respect to the one computed assuming the speed of light in vacuum could explain the null search for neutrinos in coincidence with Gamma-Ray Burst

The conjugacy problem for the automorphism group of the random graph

We prove that the conjugacy problem for the automorphism group of the random graph is Borel complete, and discuss the analogous problem for some other countably categorical structures.Comment: 7 page

The effectiveness of a tooth brushing programme for children in the Ehlanzeni district of Mpumalanga

PURPOSE : To evaluate the effectiveness of a tooth brushing programme in a community trial in the Ehlanzeni district, Mpumalanga. METHODOLOGY : Two samples of 250 children, 8-10 years old and in grade 3, were randomly selected from schools in the district. The intervention group comprised children who had taken part in the brushing project since it was incepted in 2012. The control group comprised children who had not participated. Caries was scored according to WHO Criteria (1997) and odontogenic infections using the PUFA/ pufa index. These data and the treatment needs of the two groups were compared statistically. RESULTS : The prevalence of dental caries (primary and permanent teeth) was 57.2%, intervention group and 74.8%, control group. The intervention group recorded DMFT of 0.15 and a dmft of 1.82, whilst the control group recorded 0.38 and 2.50 respectively. Odontogenic infections occurred in 22% of the intervention group (mean 0.40), compared with 36% in the non-intervention group (mean 0.82). The intervention group presented with 30.8% less dental caries and 63.6% less odontogenic infections than the control group. CONCLUSION : The results of the study show that this targeted population approach resulted in significantly less caries in the intervention group than in the control group.https://www.sada.co.za/the-sadjam2019Community Dentistr

Area metric gravity and accelerating cosmology

Area metric manifolds emerge as effective classical backgrounds in quantum string theory and quantum gauge theory, and present a true generalization of metric geometry. Here, we consider area metric manifolds in their own right, and develop in detail the foundations of area metric differential geometry. Based on the construction of an area metric curvature scalar, which reduces in the metric-induced case to the Ricci scalar, we re-interpret the Einstein-Hilbert action as dynamics for an area metric spacetime. In contrast to modifications of general relativity based on metric geometry, no continuous deformation scale needs to be introduced; the extension to area geometry is purely structural and thus rigid. We present an intriguing prediction of area metric gravity: without dark energy or fine-tuning, the late universe exhibits a small acceleration.Comment: 52 pages, 1 figure, companion paper to hep-th/061213

Effect of early life antibiotic use on serologic responses to oral rotavirus vaccine in the MAL-ED birth cohort study

Background: Oral rotavirus vaccine efficacy is lower in low- and middle-income countries (LMICs) than in high-income countries. The degree to which antibiotic use impacts rotavirus vaccine immunogenicity in LMICs is unknown. Using data from a multisite prospective birth cohort study of malnutrition and enteric disease, MAL-ED, we examined the effect of early life antibiotic use on the immune response to rotavirus vaccine. Methods: We assessed whether antibiotic use from birth up to 7 days following rotavirus vaccine series completion was associated with rotavirus seropositivity at 7 months of age in Brazil, Peru, and South Africa using a modified Poisson regression. We then used parametric g-computation to estimate the impact of hypothetical interventions that treated all children and alternatively prevented inappropriate antibiotic treatments on seropositivity. Results: Of 537 children, 178 (33%) received at least one antibiotic course during the exposure window. Probability of seropositivity was 40% higher among children who had at least one course of antibiotics compared with those with no antibiotic exposure (PR: 1.40, 95% CI: 1.04, 1.89). There was no significant difference by the number of antibiotic courses received or total duration of antibiotics. Treating all children with antibiotics would be associated with a 19% (95% CI: 18%, 21%) absolute increase in seropositivity at 7 months. In contrast, removing inappropriate antibiotics would result in a 4% absolute reduction (95% CI: −5%, −2%) in seropositivity. Conclusions: Early life antibiotic use was associated with increased seropositivity. However, a hypothetical intervention to remove inappropriate antibiotics would have little effect on overall seropositivity. Further investigation into the underlying mechanisms of antibiotic use on the infant gut microbiome and immune response are needed

Transporting monovalent rotavirus vaccine efficacy estimates to an external target population: a secondary analysis of data from a randomised controlled trial in Malawi

Oral rotavirus vaccine efficacy estimates from randomised controlled trials are highly variable across settings. Although the randomised study design increases the likelihood of internal validity of findings, results from trials may not always apply outside the context of the study due to differences between trial participants and the target population. Here, we used a weight-based method to transport results from a monovalent rotavirus vaccine clinical trial conducted in Malawi between 2005 and 2008 to a target population of all trial-eligible children in Malawi, represented by data from the 2015-2016 Malawi Demographic and Health Survey (DHS). We reweighted trial participants to reflect the population characteristics described by the Malawi DHS. Vaccine efficacy was estimated for 1008 trial participants after applying these weights such that they represented trial-eligible children in Malawi. We also conducted subgroup analyses to examine the heterogeneous treatment effects by stunting and tuberculosis vaccination status at enrolment. In the original trial, the estimates of one-year vaccine efficacy against severe rotavirus gastroenteritis and any-severity rotavirus gastroenteritis in Malawi were 49.2% (95% CI 15.6%-70.3%) and 32.1% (95% CI 2.5%-53.1%), respectively. After weighting trial participants to represent all trial-eligible children in Malawi, vaccine efficacy increased to 62.2% (95% CI 35.5%-79.0%) against severe rotavirus gastroenteritis and 38.9% (95% CI 11.4%-58.5%) against any-severity rotavirus gastroenteritis. Rotavirus vaccine efficacy may differ between trial participants and target populations when these two populations differ. Differences in tuberculosis vaccination status between the trial sample and DHS population contributed to varying trial and target population vaccine efficacy estimates

Abelian duality on globally hyperbolic spacetimes

We study generalized electric/magnetic duality in Abelian gauge theory by combining techniques from locally covariant quantum field theory and Cheeger-Simons differential cohomology on the category of globally hyperbolic Lorentzian manifolds. Our approach generalizes previous treatments using the Hamiltonian formalism in a manifestly covariant way and without the assumption of compact Cauchy surfaces. We construct semi-classical configuration spaces and corresponding presymplectic Abelian groups of observables, which are quantized by the CCR-functor to the category of C*-algebras. We demonstrate explicitly how duality is implemented as a natural isomorphism between quantum field theories. We apply this formalism to develop a fully covariant quantum theory of self-dual fields

Quintessential Maldacena-Maoz Cosmologies

Maldacena and Maoz have proposed a new approach to holographic cosmology based on Euclidean manifolds with disconnected boundaries. This approach appears, however, to be in conflict with the known geometric results [the Witten-Yau theorem and its extensions] on spaces with boundaries of non-negative scalar curvature. We show precisely how the Maldacena-Maoz approach evades these theorems. We also exhibit Maldacena-Maoz cosmologies with [cosmologically] more natural matter content, namely quintessence instead of Yang-Mills fields, thereby demonstrating that these cosmologies do not depend on a special choice of matter to split the Euclidean boundary. We conclude that if our Universe is fundamentally anti-de Sitter-like [with the current acceleration being only temporary], then this may force us to confront the holography of spaces with a connected bulk but a disconnected boundary.Comment: Much improved exposition, exponent in Cai-Galloway theorem fixed, axionic interpretation of scalar explained, JHEP version. 33 pages, 3 eps figure

Detecting a stochastic gravitational wave background with the Laser Interferometer Space Antenna

The random superposition of many weak sources will produce a stochastic background of gravitational waves that may dominate the response of the LISA (Laser Interferometer Space Antenna) gravitational wave observatory. Unless something can be done to distinguish between a stochastic background and detector noise, the two will combine to form an effective noise floor for the detector. Two methods have been proposed to solve this problem. The first is to cross-correlate the output of two independent interferometers. The second is an ingenious scheme for monitoring the instrument noise by operating LISA as a Sagnac interferometer. Here we derive the optimal orbital alignment for cross-correlating a pair of LISA detectors, and provide the first analytic derivation of the Sagnac sensitivity curve.Comment: 9 pages, 11 figures. Significant changes to the noise estimate

Quark and Lepton Mass Matrices in the SO(10) Grand Unified Theory with Generation Flipping

We investigate the SO(10) grand unified model with generation flipping. The model contains one extra matter multiplet $\psi(10)$ and it mixes with the usual matter multiplets $\psi_i(16)$ when the SO(10) is broken down to SU(5). We find the parameter region of the model in which the observed quark masses and mixings are well reproduced. The resulting parameter region is consistent with the observation that only $\psi_i(16)$ have a source of hierarchies and indicates that the mixing between second and third generations tends to be large in the lepton sector, which is consistent with the observed maximal mixing of the atmospheric neutrino oscillation. We also show that the model can accommodate MSW and vacuum oscillation solutions to the solar neutrino deficit depending on the form of the Majorana mass matrix for the right-handed neutrinos.Comment: 28 pages, Late